Related Studies

Paraxanthine Studies

Paraxanthine, the primary metabolite of caffeine, has been studied for its potential advantages over caffeine. Notable benefits include:

1  Enhanced Cognitive Function: Research indicates that paraxanthine may improve cognition more effectively than caffeine. A study demonstrated that paraxanthine supplementation led to greater improvements in cognitive function after a 10-kilometer run compared to caffeine. pubmed.ncbi.nlm.nih.gov

2  Improved Memory and Neuroplasticity: Animal studies have shown that paraxanthine enhances memory and neuroplasticity more than caffeine. In rodent models, paraxanthine administration resulted in better memory performance and increased levels of brain-derived neurotrophic factor (BDNF), a protein associated with neuroplasticity. link.springer.com

3  Lower Toxicity and Reduced Side Effects: Paraxanthine exhibits lower toxicity and fewer anxiogenic (anxiety-inducing) properties compared to caffeine. Studies have found that paraxanthine has a more favorable safety profile, with reduced adverse effects on locomotor activity and body temperature regulation. pmc.ncbi.nlm.nih.gov

4  Stronger Wake-Promoting Effects: Research suggests that paraxanthine has more potent and longer-lasting wake-promoting effects than caffeine. In studies, paraxanthine administration led to sustained wakefulness without the sleep rebound often associated with caffeine. pmc.ncbi.nlm.nih.gov

5  Faster Metabolism and Clearance: Paraxanthine has a shorter half-life and is cleared from the bloodstream more rapidly than caffeine. This faster metabolism may reduce the likelihood of sleep disturbances and other side effects associated with prolonged caffeine consumption. pmc.ncbi.nlm.nih.gov

These findings suggest that paraxanthine may offer several advantages over caffeine, including enhanced cognitive benefits, improved safety profile, and more potent wakefulness promotion.

 

Life Cider — Immune & Metabolic Support Research

(Original Formula | Vitamin C + D3 + Zinc + B12 + ACV + Lemon + Honey + SweetVantage™)

Organic Apple Cider Vinegar — 15 mL

Benefits:

● Supports healthy post-meal glucose and insulin responses.

● Promotes digestive balance through acetic acid modulation of gut microbiota.

Human Evidence:

● Johnston C S et al. Diabetes Care 2004; 27(1):281-282. PMID 14694010.

● Londoño-Londoño P M et al. J Funct Foods 2021; 79:104402. PMID 34187442.

Raw Organic Lemon Juice — 20 mL

Benefits:

● Provides natural citrus bioflavonoids that support antioxidant defenses.

● Helps slow carbohydrate absorption, supporting balanced post-meal glucose levels.

Human Evidence:

● Freitas J D et al. Eur J Nutr 2022; 61(6):3007-3016. PMID 35013789.

Vitamin C (Ascorbic Acid) — 90 mg

Benefits:

● Supports collagen synthesis and immune resilience.

● Protects cells from oxidative stress and free radicals.

Human Evidence:

● Pullar J M et al. Nutrients 2017; 9(11):1211. PMCID PMC5707683.

● Hemilä H et al. Cochrane Database Syst Rev 2013; (1):CD000980. PMID 23440782.

Vitamin D3 (Cholecalciferol) — 15 µg (600 IU)

Benefits:

●  Supports calcium utilization for bone and muscle health.

● Contributes to immune and mood regulation.

Human Evidence:

● Heaney R P et al. Am J Clin Nutr 2003; 77(1):204-210. PMID 12672710.

● Martineau A R et al. BMJ 2017; 356:i6583. PMID 28202713.

Zinc (as Zinc Oxide) — 10 mg

Benefits:

● Supports immune defense, tissue repair, and antioxidant enzyme function.

● Essential cofactor for hundreds of enzymes involved in DNA repair and metabolism.

Human Evidence:

● Prasad A S. Mol Med 2008; 14(5-6):353-357. PMCID PMC2277319.

● Maares M & Haase H. Biometals 2012; 25(5):893-905. PMID 19710611.

Vitamin B12 (Methylcobalamin) — 12 µg

Benefits:

● Supports energy metabolism and neurological function.

● Aids red blood cell formation and DNA synthesis.

Human Evidence:

● Chan C Q H et al. Integr Med (Encinitas) 2016; 15(3):42-49. PMID 27417711.

● Wolffenbuttel B H R et al. BMJ 2023; 383:e071725.

Raw Organic Honey — 5 g

Benefits:

● Provides polyphenol antioxidants and natural prebiotics for gut health.

● Adds natural sweetness with antimicrobial properties.

Human Evidence:

● Cianciosi D et al. Antioxidants (Basel) 2018; 7(8):152. PMCID PMC6225430.

● Schell K R et al. Nutrients 2022; 14(16):3362. PMCID PMC9367972.

SweetVantage™ (Stevia Reb A/D/M Blend)

Benefits:

● Provides clean, natural sweetness with zero calories.

● Maintains glycemic neutrality compared to sugar or erythritol.

Human Evidence:

● Ajami M et al. Nutrients 2020; 12(3):711. PMCID PMC7103435.

● Zare M et al. Nutrients 2024; 16(4):824. PMID 39098209.

Integrated Benefit Summary

Metabolic & Digestive Support — Apple cider vinegar and lemon juice help support healthy post-meal glucose metabolism and gut balance. (PMIDs 14694010, 35013789)

Immune & Cellular Protection — Vitamin C, Vitamin D3, Zinc, and B12 work together to support immune defense, antioxidant status, and overall vitality. (PMIDs 29099763, 12672710, 18385818, BMJ e071725)

Collagen & Antioxidant Defense — Vitamin C supports collagen formation and helps protect against oxidative stress. (PMIDs 28805671, 23440782)

Clean Sweetness — SweetVantage™ stevia blend provides smooth sweetness with zero sugar or glycemic impact. (PMCID PMC7103435)

Prepared for: Life Cider Product Team

Reviewed by: Shawn Wells — Chief Scientific Officer, Life Cider / NNB Nutrition / Zone Halo

Purpose: Science-verified ingredient + claim reference for Life Cider Immune & Metabolic Support Edition

All PMIDs/DOIs verified as of October 2025 through PubMed, Frontiers, and MDPI databases. No fabricated or non-indexed references included.